Work on the project “Global mapping of drug synergy landscapes using massively parallel Cas13d genetic interaction screening” within the German Cancer Aid-funded DEFEAT-PDAC consortium
Investigate therapeutically relevant genetic dependencies and drug combinations in pancreatic ductal adenocarcinoma
Perform and analyze high-throughput genetic interaction screens, particularly using Cas13d-based screening approaches
Plan and conduct molecular and cell biological experiments to validate identified targets and drug synergies
Investigate rational combination therapies, including combinations with RAS/KRAS inhibitors
Work with pancreatic cancer cell lines and additional preclinical model systems
Apply modern methods in cell biology, molecular biology, functional genomics and proteomics
Quantitatively analyze, interpret and document experimental data
Collaborate closely with research groups and technology platforms within the DEFEAT-PDAC network
Present research findings at project meetings and scientific conferences and contribute to scientific publications
Our requirements
A successfully completed university degree, preferably a Master’s degree or equivalent, in biology, biochemistry, molecular medicine, biotechnology or a related life-science discipline
Strong interest in cancer biology, functional genomics, mechanisms of therapy resistance and translational cancer research
Practical experience in cell and molecular biology, for example mammalian cell culture, transfection, RNA and protein analysis, immunoblotting or microscopy
Previous experience with CRISPR-based technologies, genetic screens, proteomics, next-generation sequencing or bioinformatic data analysis is an advantage, but not mandatory
Motivation to learn new experimental technologies and quantitative analysis methods
A careful, structured and independent approach to scientific work
Scientific curiosity, high motivation and enthusiasm for experimental research
Strong communication and teamwork skills and an interest in working in an interdisciplinary and international research environment
Very good written and spoken English
German language skills are not required
Our offer
An innovative and challenging PhD project within the DEFEAT-PDAC consortium, a national and internationally connected research network funded by German Cancer Aid
An international and interdisciplinary research environment at the interface of cancer biology, functional genomics, proteomics and clinical translation
State-of-the-art laboratories and access to advanced screening, proteomics, sequencing and data-analysis platforms
Close collaboration with basic scientists, bioinformaticians and clinician scientists
Structured scientific supervision and support for your professional and personal development
Opportunities to participate in national and international conferences, workshops and training programmes
A collaborative, supportive and inspiring working environment that encourages scientific independence and the development of your own ideas
Employment according to the German public-sector collective agreement, including annual leave and additional benefits in accordance with the applicable regulations
The position is initially funded for three years. Subject to a positive scientific re-evaluation, an extension for up to two additional years is possible
The position is based at the LMU University Hospital, Campus Großhadern, in Munich
The remuneration is based on the Collective Agreement for the Public Service of the Federal States (TV-Ärzte) including all allowances customary in the public service.
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